ASBT is Na-dependent uptake transporter of bile acids and conjugates. It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs [1]. Although ASBT is expressed in other organs, its functions there are largely unexplored.

petromyzonol sulfate (its endogenous bile salt) with high affinity, but taurocholate with low affinity. The multi-tissue expression pattern suggests that lamprey Slc10a1 can transport other substrates in addition to bile salt. The Na+-taurocholate cotransporting polypeptide (NTCP, SLC10A1) is a liver specific bile salt transporter

Hepatocellular bile salt uptake is mediated predominantly by the Na + -taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na + -independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). After diffusion (bound by intracellular bile salt–binding proteins) to the canalicular patic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na -dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na - taurocholate cotransporting polypeptide NTCP (SLC10A1). Other bile salt transporters include the organic The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of bile salt and Na with the membranal recognition site of this transport system. The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. 2003-04-01 · Bile salt uptake via Ntcp/NTCP is unidirectional with a sodium-to-taurocholate stoichiometry of 2:1, i.e., cotransport of two Na + with one taurocholate molecule, and electrogenic, i.e., it is driven by both the transmembrane Na + gradient which in turn is maintained by a Na +-K +-ATPase and the intracellular electrical potential derived from the outward diffusions of K + (210, 245).

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Hur mycket upptag av gallsyror är neutrala gallsyror, jf med gallsalt (vilka är laddade)?. 10ggr fler Co-transport med Na. Bile acid receptor (BAR/FXR). Vid klinisk relevant plasmakoncentration hämmar velpatasvir inte levertransportörerna BSEP (bile salt export pump), NTCP (sodium taurocholate cotransporter  av G Englund · 2005 — Sodium/taurocholate cotransporting polypeptide. OATP. Organic peptides, sugars, bile acids/salts, metal ions, vitamins, phosphate, nucleo-. BSEP (bile salt export pump), OATP1B1, OATP1B3 och OCT1 (organic cation NTCP (sodium taurocholate cotransporter protein), OATP1A2 eller OCT1,  At clinically relevant plasma concentration, velpatasvir is not an inhibitor of hepatic transporters bile salt export pump (BSEP), sodium taurocholate cotransporter  Airborne clay dust salt and soot particles are typically nanoparticles Furosemide and other loop diuretics inhibit the Na K Cl transporter in the thick whereas thiazide diuretics inhibit the Na Cl cotransporter at the early T tube tube placed in the bile duct for drainage into a small pouch bile bag on the  Det tar ca 8 sekunder för maten att nå gaster från sodium-glucose cotransporter.

Det tar ca 8 sekunder för maten att nå gaster från sodium-glucose cotransporter. Detta genom en ATP-beroende transportör, bile salt export pump, BSEP. 2.

Lägga till sterila PEG 8000 i fosfatbuffrad saltlösning (PBS) insamlade medellång till en Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes. av I Tasevska — to salt sensitivity, coronary artery disease (CAD) as well as cardiovascular (CV) mortality and chronic kidney Od sekogas vie ste bile pokraj alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.

Hur mycket upptag av gallsyror är neutrala gallsyror, jf med gallsalt (vilka är laddade)?. 10ggr fler Co-transport med Na. Bile acid receptor (BAR/FXR).

Changing glomerular filtration rate (video) | Khan Academy. Clinically used  Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa. Function.

The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate proteoglycans, 25 which are found on a variety of cells, and clathrin-mediated endocytosis. 26 The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. Hepatocellular bile salt uptake is mediated predominantly by the Na + -taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na + -independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans).
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1 ways to abbreviate Na(+)-bile Salt Co-transporter.

petromyzonol sulfate (its endogenous bile salt) with high affinity, but taurocholate with low affinity.
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Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer].

In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na(+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. 1 ways to abbreviate Na(+)-bile Salt Co-transporter.